Tmed10 translocation
WebNational Center for Biotechnology Information WebDec 11, 2024 · TMED2 is a type I membrane protein that contains a transmembrane (TM) domain, a coil-coiled (CC) domain, and a Golgi dynamics (GOLD) domain. The GOLD domain is a β strand-rich domain involved in Golgi dynamics and intracellular protein trafficking ( Carney and Bowen, 2004, Luo et al., 2007, Strating and Martens, 2009 ).
Tmed10 translocation
Did you know?
WebApr 30, 2024 · TMED10 Is Required for the Secretion of Mature IL-1β in Inflammatory and Non-inflammatory Cells. IL-1β is a most intensely investigated UPS cargo that undergoes … WebApr 10, 2024 · The interaction of TMED10 C-terminal region with a motif in the cargo accounts for the selective release of the cargoes. In an in vitro reconstitution assay, TMED10 directly mediates the membrane translocation of leaderless cargoes into the liposome, which is dependent on protein unfolding and enhanced by HSP90s.
WebApr 30, 2024 · In the cell, TMED10 localizes on the endoplasmic reticulum (ER)-Golgi intermediate compartment and directs the entry of cargoes into this compartment. … WebJun 27, 2024 · It has been suggested that HSP90A then unfolds IL-1β to expose a signal motif allowing direct translocations into the ERGIC through transmembrane Emp24 domain-containing protein 10 (TMED10) (Figure 3C). Of note, the import of IL-1β by TMED10 is also aided by HSP90B1, although HSP90B1 mechanistic contributions are less well understood .
WebMar 10, 2024 · Misexpression studies revealed that TMED10 attenuated TGF-β-mediated signaling. A 20-amino acid-long region from Thr 91 to Glu 110 within the extracellular region of TMED10 was found to be crucial for TMED10 interaction with both ALK5 and TβRII. Synthetic peptides corresponding to this region inhibit both TGF-β-induced Smad2 … WebNov 19, 2009 · These include stress sensing and signalling, protein folding, translocation, vesicular transport and ER-associated degradation. Genes known or predicted by sequence homology to play a physiological role in secretion or …
WebApr 15, 2024 · The role of CDR1as in 293 T cells. We began by measuring the expression of CDR1as in a variety of cell lines, revealing it to be expressed at high levels in the 293 T, THLE-3, Hep3B, MCF-7, and A549 cell lines (Fig. 1a). Expression was markedly elevated in 293 T cells, with levels 100 times higher than those in the Huh7, MS751, and LoVo cell lines.
WebTMED10 contains a single transmembrane domain, a luminal signal peptide (SS), a Golgi dynamics (GOLD) domain, a coil-coil (CC) domain and a C-terminal tail (CT) facing the … oftedal reviewsWebUPS货物在分泌过程中，诱导TMED10同源寡聚物的形成，随着分泌的完成，同源寡聚物逐渐解聚。. UPS货物可能在这个过程中发生迁移，说明TMED10介导一种蛋白质通道。. 根据自己的研究成果，作者提出图1所示的TMED10介导的蛋白质非经典分泌途径（TMED10-channeled UPS , THU ... oftedgeWebFull gene name according to HGNC. Transmembrane p24 trafficking protein 10. Gene namei. Official gene symbol, which is typically a short form of the gene name, according to … oftedal casper wyWebSep 28, 2024 · TMED10 belongs to a family of type I transmembrane (TM) proteins with a large domain and a short cytosolic tail ( Emery et al., 2000 ; Gommel et al., 1999 ). TMED members can hetero-oligomerize, and TMED10 in particular has been shown to dimerize with TMED2 ( Zavodszky and Hegde, 2024 ). oft edge의 지원 받기WebFeb 9, 2010 · “TCGA Gene analysis” module was used to analyze mRNA levels of the TMED2/9/10 in HNSC patients and healthy individuals and their correlation with … my friend changed his netflix passwordWebDec 16, 2024 · And the oligomerized TMED10 may form a potential channel to mediate cargo translocation. They further verified that TMED10 directly mediates the membrane … oft edge help \u0026 learningWebApr 10, 2024 · tmed10介导的蛋白质非经典分泌途径工作模型 在这项研究中，研究人员鉴定出一个膜蛋白TMED10可能形成一个蛋白通道介导UPS蛋白进入囊泡结构。 细胞实验发现，TMED10能够调控大量非经典分泌蛋白的分泌，包括炎症因子IL-1家族成员，galectin1和galectin3，以及小分子 ... oftedal transport